Endocrine Abstracts

Purpose: Agouti-related protein (AgRP) is known as an orexigenic neuropeptide which is expressed in the hypothalamic arcuate nucleus. It’s possible AgRP is an important molecule in glucocorticoid (GC) induced obesity (e.g. Cushing syndrome), because GC positively regulate hypothalamic AgRP. To clarify the role of AgRP in GC-induced obesity, we investigate here the effect of GC on AgRP deficient mice.Methods: Male wild-type littermates (n=20...

Purpose: Glucocorticoid is one of the key hormones that regulates energy balance. Glucocorticoid excess induce hyperphagia and obesity (e.g. Cushing syndrome), however, its mechanisms are not fully elucidated. On the other hand, Agouti-related protein (AgRP) is known as an orexigenic neuropeptide, which is expressed in the hypothalamic arcuate nucleus. To clarify the role of Agouti-related protein (AgRP) in glucocorticoid-induced obesity, we investigate here the effect of gluc...

Background: Anaplastic thyroid carcinoma (ATC), which is one of the most aggressive endocrine tumors. Primary thyroid carcinoma typically does not interfere with thyroid function and presentation of ATC with thyrotoxic state is extremely rare. We present here an ATC patient who is complicated with thyrotoxicosis.Case: A 69-year-old man presented with neck swelling and pointed out thyroid tumor with calcification two years ago. He appeared general fatigue...

Background: Acute invasive fungal rhinosinusitis (AIFR) is a rare but fatal infection that occurs primarily in immunocompromized individuals. It is characterized by fungal invasion into the mucosa and submucosal structures of the paranasal sinuses with extension into adjacent structures, including the paranasal soft tissues, orbit and cranial vault. We present here a case of hypopituitarism due to AIFR with intracranial lesion.Case: A 59-year-old man, wh...